3-[2-(Acetylamino)ethyl]-5-methoxy-1H-indole-6-ol
6-Hydroxy Melatonin
CAS: 2208-41-5
Molecular Formula: C13H16N2O3
3-[2-(Acetylamino)ethyl]-5-methoxy-1H-indole-6-ol - Names and Identifiers
3-[2-(Acetylamino)ethyl]-5-methoxy-1H-indole-6-ol - Physico-chemical Properties
| Molecular Formula | C13H16N2O3 |
| Molar Mass | 248.28 |
| Density | 1.266±0.06 g/cm3(Predicted) |
| Melting Point | 172-175°C |
| Boling Point | 564.7±50.0 °C(Predicted) |
| Solubility | alcohol: soluble |
| Appearance | Solid |
| Color | White to Beige |
| pKa | 10.12±0.40(Predicted) |
| Storage Condition | Refrigerator |
| Physical and Chemical Properties | The original medicine is a clear amber or yellow liquid with an aromatic taste. B. p.71 ℃/133.3Pa (content 96% ~ 98%). Flash point 115.5 ℃, relative density 0.9402 (25 ℃), vapor pressure 0.173Pa (25 ℃). It can be miscible with acetone, ethanol, xylene, kerosene, methyl isopentan-2-one, and the solubility in water at 20 ℃ is 46mg/L. Non-corrosive. |
3-[2-(Acetylamino)ethyl]-5-methoxy-1H-indole-6-ol - Risk and Safety
| Risk Codes | R22 - Harmful if swallowed R40 - Limited evidence of a carcinogenic effect R51/53 - Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. R20 - Harmful by inhalation |
| Safety Description | S36/37 - Wear suitable protective clothing and gloves. S60 - This material and its container must be disposed of as hazardous waste. |
| WGK Germany | 3 |
| RTECS | AC3607000 |
3-[2-(Acetylamino)ethyl]-5-methoxy-1H-indole-6-ol - Reference Information
| Application | The scientific name S-ethyl-N,N-diisobutyl thiocarbamate, common name butyl ester. Clear liquid with aromatic odor, relative density 0.9417, boiling point 138 ℃(21 × 133.322). Insoluble in water, miscible with kerosene, xylene and methyl isobutyl ketone. Non-corrosive. It is prepared by reacting diisobutylamine with phosgene to form carbamoyl chloride and then with ethyl mercaptan. As a herbicide, it can be used to control broad-leaved and narrow-leaved weeds in corn fields. |
| toxicity | Acute oral LD50 was 4560mg/kg in male rats and 5431mg/kg in female; rabbit acute percutaneous LD50>4640mg/kg. LC50 was 17.6mg/L in rats with acute exingement. It has a slight stimulating effect on the skin of rabbits. Rats were fed for 90 days at doses of> 32mg/kg per day and dogs at doses of> 48mg/kg per day. Mice fed for 2 years Test No effect dose was> 320mg/kg per day. The teratogenic, carcinogenic and mutagenic effects were not found in animal experiments. The LC50 of rainbow trout was 4.2mg/L (96H), The LC50 of carob was 6.9mg/L (96H), and the LD50 of quail was> 5600mg/kg. Low toxicity to bees. |
| biological activity | 6-Hydroxymelatonin is a major metabolite of Melatonin metabolized by CYP1A2. |
| Use | selective pre-emergence soil treatment. Through the weed Bud (Gramineae by coleoptile, dicotyledons by hypocotyl) absorption, can in vivo conduction, inhibition and destruction of nucleic acid metabolism and protein synthesis, inhibition meristematic tissue growth and play a role. The drug-treated weed could not be discovered or the growing point was broken; The aerial part of the discovered weed was not rolled, and the stem was swollen, friable and easy to fold. It is suitable for the control of annual Gramineae weeds, such as humulus scandens, sweet corn, green barley feed corn, spinach and lettuce, etc; on the seed germination of perennial weeds, such as dog tooth root, root sorghum, Cyperaceae, cyperus, oil Cyperus and so on also have control effect. Before maize sowing, the effective component is 34.1g/100 m2 for sandy soil, 45g/100 m2 for heavy clay soil, and 4.5 ~ 7.5kg of water under low pressure. This medicine is highly volatile, should adopt high capacity and low pressure spray. Can be mixed with atrazine, grass and 2,4-butyl ester. The addition of R-25788 safener in Xudan emulsion can increase the drug resistance of maize. |
| production method | ethylthioformyl chloride is prepared by the reaction of ethanethiol and phosgene in the presence of tertiary amine, then, the compound was reacted with diisobutylamine to synthesize butene. |
Last Update：2024-04-10 22:29:15
![3-[2-(Acetylamino)ethyl]-5-methoxy-1H-indole-6-ol](http://res.chembk.com/assets/str/2d/2/22/2208-41-5.png)
Supplier List
Multiple Specifications
Product Name: 6-Hydroxy Melatonin Visit Supplier Webpage Request for quotationCAS: 2208-41-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Multiple Specifications
Product Name: 6-Hydroxy Melatonin Visit Supplier Webpage Request for quotationCAS: 2208-41-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
View History